Acetyl Lysine Antibody, FITC(ICP0385)

Applications:
For direct immunofluorescence experiments
Immunogen:
Acetylated KLH conjugates
Species:
Rabbit
Formulation:
250 µg/mL in PBS (pH 7) with 50% glycerol
Conjugation:
FITC:antibody = 10:1
Pack Size
Price (USD)
Quantity
100 µg
$375.00
In Stock Request a Bulk Order
  • Product Description

    The rabbit anti-acetyl lysine antibody is developed using acetylated KLH as the immunogen. It is then affinity purified with acetyl lysine agarose, followed by conjugation with fluorescein isothiocyanate.
  • Scientific Description

    Acetylation of lysine is an important, reversible modification. The activities of some proteins are controlled by acetylation of lysine. Histone acetyltransferases (HATs) acetylate the conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) that contain lysine residues. Histone deacetylases (HDACs) remove the acetyl group from the same residue. [1] Acetylation/deacetylation of histones results in cell signalling processes that include gene activity, cell growth, differentiation and apoptosis. [2] In cancer and polyglutamine diseases, the regulation of protein acetylation/deacetylation is impaired (7). Numerous anti-cancer drugs target HDACs. [3]
  • Storage & Stability

    Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is six months from date of shipping if stored properly.

  • Product Specific References

    1.  1. Curr. Opin. Chem. Biol. 1997. 1(3): 300-308. doi:10.1016/S1367-5931(97)80066-X.
    2.  2. Curr. Cancer Drug Targets. 2004. 4(2): 205-218.  doi:10.2174/1568009043481560.
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