Acetyl Lysine Antibody, HRP(ICP0381)

For direct immunofluorescence experiments
The antibody recognizes proteins acetylated on lysine residues. Tested: acetylated histone, acetylated BSA and acetylated MBP. No cross-reaction to the non-acetylated proteins.
Acetylated KLH conjugates
250 µg/mL in stabilizing buffer with 50% glycerol
Reductive amination; HRP:Ab molar ratio =10:1
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  • Product Description

    The rabbit anti-acetyl lysine antibody (anti-AcK) is developed using acetylated KLH as the immunogen. It is then affinity purified with acetyl lysine agarose, followed by conjugation with horseradish peroxidase (HRP).
  • Scientific Description

    DNA transcription cannot take place unless DNA is unwound from the nucleosomes. The cell unwinds the DNA by acetylating the lysine residues within the proteins. It has been suggested that acetylation of non-histone proteins (e.g. transcription factors) and histones may be involved. Acetylation of the proteins may result in signal transduction within the chromatic domains.

  • Storage & Stability

    Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is six months from date of shipping if stored properly.

  • Product Specific References

    1. Curr. Opin. Chem. Biol. 1997. 1(3): 300-308. doi:10.1016/S1367-5931(97)80066-X.

    2. Curr. Biol. 2002.12(4): R141-R143. doi:10.1016/S0960-9822(02)00709-1.

    3. J. Cel. Rep. 2014. 7(5): 1471-1480. doi:10.1016/j.celrep.2014.04.021.

    4. Biosci. Rep. 2017. BSR20170157. doi: 10.1042/BSR20170157

    5. Bioscience Reports 2017. 37(4): BSR20170157. doi:10.1042/BSR20170157.

    6. Mol. Microbiol. 2017. 103(5): 845-859. doi:10.1111/mmi.13595

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