Maturation of mitogen-activated protein kinase (MAPK), also known as extracellular signal regulated kinase 2 (ERK2), is involved in the eukaryotic signalling process. [1] It is activated by a dual phosphorylation on threonine and tyrosine residues by the dual-specificity kinase MKK1/2. After stimulation, ERK2 p42 translocates to the nucleus. [2] Once phosphorylated, ERK2 can form dimers with phosphorylated and unphosphorylated ERK2 partners. ERK2 can also phosphorylate many substrates, for instance EGFR, c-PLA2, Elk1/TCF and c-Myc. [3-5]

Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.

1. J. Biol. Chem. 1991. 266(23): 15266–15276.
2. Mol. Cell Biol. 1992. 12: 915–927. doi:10.1128/MCB.12.3.915
3. Cell. 1993. 72: 269–278. doi:10.1016/0092-864(93)90666-E
4. J. Biol. Chem. 1992. 267(34): 24796-24804.