Acetyl lysine antibody biotin is an affinity purified polyclonal rabbit anti-acetylated lysine antibody and is developed using acetylated KLH as the immunogen. The acetylated lysine-specific antibody is conjugated with d-Biotin via amine acylation.

DNA transcription cannot take place unless DNA is unwound from the nucleosomes. The cell unwinds the DNA by acetylating the lysine residues within the proteins. It has been suggested that acetylation of non-histone proteins (e.g. transcription factors) and histones may be involved. Acetylation of the proteins may result in signal transduction within the chromatic domains.

Product is stable for several weeks at 4°C. For extended storage, store product at -20°C. Expiration date is one year from date of shipping if stored properly.

1. FEBS Lett. 2002. 513(1): 124-128. doi:10.1016/S0014-5793(01)03309-9.