p70 S6K is a protein serine/threonine kinase that exists ubiquitously. [1] p70 S6K affects the activities of the cell cycle. p70 S6K is an important regulator of cell proliferation. [2] p70 S6K activation requires sequential phosphorylation at proline-directed residues in the putative auto-inhibitory pseudo-substrate domain, as well as threonine 389. Activation of p70 S6K requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s).

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2. J. Biol. Chem. 1996. 271(2): 963-971. doi:10.1074/jbc.271.2.963
3. Mol. Cell Biol. 1999. 19(4): 2921-2928. doi: 10.1128/mcb.19.4.2921