A knock in mouse with biotin at the titin’s Z disc region to identify protein networks that connect the sarcomere to signal transduction and metabolism | Immunechem

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A knock in mouse with biotin at the titin’s Z disc region to identify protein networks that connect the sarcomere to signal transduction and metabolism

A knock in mouse with biotin at the titin’s Z disc region to identify protein networks that connect the sarcomere to signal transduction and metabolism

November 18th, 2022

Figure 1. The biotin ligase (blue dot) is integrated between titin Ig7 and Ig8 folding back to the edge of the Z-disc.

Rudolph. F., Fink. C., Hüttemeister J., et al. Deconstructing sarcomeric structure-function relations in titin-BiolD knock-in mice. Nature Communications. 2020. 11: 3133.

In the journal of Nature Communications, ImmuneChem’s Anti-Biotin Agarose (ICP0615) was used during the pull down experiment to enrich biotinylated peptides.