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Acetyl Lysine Antibody (ICP0380) was used in the immunoblotting experiments to identify deacetylation of SIRT2 in the cell.

ImmuneChem’s Acetyl Lysine Antibody (ICP0380) was used in the immunoblotting experiments to identify deacetylation of SIRT2 in the cell.

Head. P. E., Kapoor-Vazirani. P. L., Nagaraju. G. P., et al. DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. Nucleic Acids Research. 2023. 51(15): 7972-7987.

In the article, Acetyl Lysine Antibody (ICP0380) was used in the immunoblotting experiments to confirm the deacetylation of SIRT2 process, which was a critical step in the research. Once SIRT2 was deacetylated, DNA-PK would be activated and bound to Ku heterodimer to promote the repair of double strand DNA break repair by non-homologous end joining.